Why do tauroursodeoxycholic acid is better than ursodeoxycholic acid?
Tauroursodeoxycholic acid is known as a new generation of bile acid drugs or as a third generation bile acid drug and is commonly used in ursodeoxycholic acid in chemistry. Structure, onset speed, drug metabolism, effectiveness, and safety are somewhat different, showing more advantages, as follows:
1.Tauroursodeoxycholic acid is a new compound. It is a new substance produced by a combination of a multi-step chemical reaction and taurine based on ursodeoxycholic acid. Their chemical structure and physicochemical properties.
There are significant differences.
Structure of ursodeoxycholic acid
Structure of Tauroursodeoxycholic acid
The Tauroursodeoxycholic acid molecular side chain has more polar group taurine groups than ursodeoxycholic acid. The ursodeoxycholic acid is a naturally occurring binding bile acid in the human body, which is physiologically active and more Hydrophilic. More soluble in water.The presence of side chain taurine groups has a protective effect, which results in less biotransformation of ursodeoxycholic acid than ursodeoxycholic acid, which is also absorbed in a different manner than ursodeoxycholic acid.
Tauroursodeoxycholic acid buys directly exerts physiological effects.
Studies have shown that ursodeoxycholic acid requires a combination of amidation and taurine to exert physiological effects more effectively. Tauroursodeoxycholic acid is a combination of bile acids that can act directly. Play a pharmacological role, clinically, Tauroursodeoxycholic acid can treat cholesterol stones, effectively cross, the efficiency of dissolved stone is higher.
- Tauroursodeoxycholic acid is more hydrophilic, can better hydrolyze the bile acid pool, and reduce the toxicity of hydrophobic bile acids in bile.
- Tauroursodeoxycholic acid has a higher bioavailability than ursodeoxycholic acid, and non-conjugated bile acids such as ursodeoxycholic acid are mainly absorbed in a passive manner. That is passive absorption of the upper part of the small intestine due to diffusion of the difference in concentration. The bound bile acids are primarily absorbed by the active transport of transporters at the terminal ileum. The absorption efficiency of active transport is much higher than the absorption efficiency of passive diffusion. Secondly, the conversion rate of tauroursodeoxycholic acid is low, so its bioavailability is high.
Tauroursodeoxycholic acid is safer than ursodeoxycholic acid. Toxicological studies using rats and mice have shown a semi-lethal dose of Tauroursodeoxycholic acid It is about 10 times that of ursodeoxycholic acid.
- Tauroursodeoxycholic acid is ingested faster than ursodeoxycholic acid, transporting and excreting quickly.
TheTauroursodeoxycholic acid and ursodeoxycholic acid mainly enter the intestinal hepatic circulation, exerting pharmacological effects on the quality of hepatobiliary diseases, and tauroursodeoxycholic acid can be more effective. Absorbed by the intestines, stem cells are absorbed faster, transported and excreted. The maximum intrahepatic transport and bile secretion rate of Tauroursodeoxycholic acid is 7 times that of ursodeoxycholic acid.
Therefore, Buy tauroursodeoxycholic acid is a new generation of bile acid drugs, which has more advantages and has higher clinical application value.