RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was formerly under investigation by ProStrakan (previously ProSkelia and Strakan) for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss[1], and excessive hair growth. The compound is similar in structure to the NSAA RU-58642 but contains a different side-chain.These compounds are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly.RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin.
RU-58841 produces cyanonilutamide (RU-56279) and RU-59416 as metabolites in animals.Cyanonilutamide has a relatively low affinity for the androgen receptor but shows significant antiandrogenic activity in animals.RU-59416 has a very low affinity for the androgen receptor.
Legality
RU58841 not FDA approved,RU58841 is classified as a chemical and can be purchased by pharmacists in the US for their own independent research.
Specification:RU58841 pure powder
White powder,RU58841 is very soluble in pure (95-96%) ethanol.
How Does RU58841 Work?
RU58841 works by counteracting the effects of DHT (and other androgens – but DHT is the important one here) on your hair follicles.
Cyanonilutamide, which is derived from RU58841, attaches itself to your hair follicle, blocking DHT from binding to it.
It’s through this same mechanism that RU58841 may be useful for treating acne, which is an androgen-related condition.
A major difference between RU58841 and other male pattern baldness treatments is that its topical use allows these effects to remain localized at the hair follicles. This can prevent a number of unpleasant side effects, which we’ll get into shortly.
RU58841 behaves differently than many other male pattern baldness treatments, which may be key in understanding why it seems to work so well.
Side Effects
Some reported side effects include the following:
- Headache
- Dizziness
- Chest pain
- Fatigue
- Low libido
- Erectile dysfunction
- Low mood
- Red eyes
- Blurry eyes
- Skin irritation
Dosage and Stack
Dosage
Take a 50 ml glass beaker and scoop ~2.5 grams of RU58841，dissolve the powder in 35 ml of 70% ethyl alcohol and 15 ml of propylene glycol. This will result in a 5% RU58841 in 50 ml, or 50mg/ml.
Dosage form application
Dilute liquid scalp using.
Stack
Minoxidil
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