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P21 gene is an important member of the cyclin-dependent kinase inhibitor family discovered recently. It is not only closely related to tumor inhibition, but also can coordinate the relationship between cell cycle, DNA replication and repair by inhibiting the activity of Cyclin-dependent kinases CDKs complexes, thus closely linking tumor inhibition with cell cycle control. The discovery and cloning of p21 gene and its important role in cell cycle control and tumorigenesis. The polymorphism of P21 gene is associated with the susceptibility to some malignant tumors, but the relationship between the polymorphism of P21 gene and the susceptibility to esophageal cancer is rarely reported.

Benefits of P21

Us researchers say they have discovered another important gene linked to ageing, adding to the list of genes that make us old and may cause diseases such as arthritis and Alzheimer’s. In all, the scientists identified 61 genes linked to aging. The newly discovered gene, P21, not only has a direct effect on cells, but also appears to control several other genes involved in decay and disease. Igor, of the University of Illinois at Chicago’s Academy of Sciences, who led the study. “When this gene is activated, many other genes involved in aging and age-related diseases are changed,” Roningsson said. Writing in the Proceedings of the National Academy of Sciences, Roningsson’s team says the finding shows that it is possible to identify this single gene and influence many of the processes of aging. The P21 gene has an inhibitory effect on cells, stopping them from growing if they are damaged by toxins or radiation, and giving them time to rest and repair themselves. In addition, when cells get too old, it inhibits cell division and initiates a process called senescence that leads to natural cell death. Further studies showed that the P21 gene interfered with more than 40 genes involved in deoxyribose replication and cell division. In addition, the P21 gene also promoted the activity of about 50 other genes. Many of these genes control the formation of proteins that either prevent surrounding cells from dying or stimulate their growth. This could mean that the P21 gene is also involved in cancer.

Dosages of P21

The best P21 dose is 1 mg a day taken intranasally and then slowly bumped up to 2-4 mg if one wants to increase acute effects.

Furthermore, depending on your individual chemistry, you may even find 500 micrograms of P21 is enough to give you the desired boost in cognition.

Dosage form application

  • Pure powder form without excipients for research use.
  • Diluted liquid.

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