Spermidine, also known as spermidine trihydrochloride, is a compound found in many natural substances. In recent years, many studies have shown that spermidine has a variety of health effects, such as anti-cancer, anti-aging, cardiovascular protection, prevention of Alzheimer’s and so on. A new study on spermidine was published in the April 13, 2021 issue of Cell Reports.
Spermidine promotes protein abundance in mitochondria during brain aging and helps maintain normal function; The anti-aging effects of spermidine rely on EIF5A-hydroxybutylysine modification, and hydroxybutylysine modification levels in the brain decrease with age, but hydroxybutylysine modification levels can be maintained through dietary supplementation until middle age. That is, dietary supplement of spermidine can prevent premature brain aging and prolong life.
Benefits of Spermidine 3HCL
1. Delay aging and prolong life
In 2009, a study published in Cell Biology confirmed that spermidine can induce transcription of autophagy related genes, thereby enhancing autophagy and inhibiting oxidative stress and necrosis of cells. In the same year, the journal of Experimental Gerontology reported that a diet rich in polyamines reduced mortality in elderly mice.
2. Fight cancer
Several studies have shown that spermidine supplementation can reduce tumorigenesis in mice, such as reducing the incidence of visible skin tumors in elderly female mice and slowing the growth of colorectal tumors in mice. Reduce the incidence of liver cancer in mice with severe liver fibrosis. Other studies have found that spermidine can enhance the anti-tumor immune response.
3. Cardiovascular protection
In 2016, research published in Atherosclerosis confirmed that spermidine reduces lipid buildup in atherosclerotic plaques. In the same year, a study published in Nature Medicine confirmed that spermidine can reduce heart hypertrophy and improve diastolic function, thus achieving the role of heart protection, and can extend the lifespan of mice.
4. Regulate and protect nerves
In 2011, research published in Investigative Ophthalmology & Visual Science found that in mice with autoimmune encephalomyelitis, oral arginine slowed disease progression and reduced damage to retinal ganglion cells, Improved visual function.
5. Improve metabolic diseases
In 2014, a study in The European Journal of Pathology showed that spermidine supplementation improved glucose utilization and significantly reduced body weight in obese mice.
In 2017, research published in Cell Death & Disease, a subsidiary of Nature, showed that spermidine was able to reduce weight gain caused by a high-calorie diet and improve obesity-related symptoms in mice.
Dosages of Spermidine 3HCL
Take 5mg orally up to 1 time daily.
Dosage form application
- Pure powder form without excipients for research use.
- Tablet or capsule for prescription use.
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